Interleukin-1,
or IL-1, is a signaling molecule that plays an important role in inflammatory
response. The cells that secrete IL-1 have receptors on their cell surface that
bind these molecules, resulting in autocrine signaling. Local intercellular
communicatio Synagen IQ n is the province of the paracrine, also called a paracrine factor,
which is a chemical that induces a response in neighboring cells. Although
paracrines may enter the bloodstream, their concentration is generally too low
to elicit a response from distant tissues. A familiar example to those with
asthma is histamine, a paracrine that is released by immune cells in the
bronchial tree. Histamine causes the smooth muscle cells of the bronchi to
constrict, narrowing the airways.
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